Thông tin cần biết về thuốc Levothyroxine

The recommended starting daily dosage of SYNTHROID in adults with primary, secondary, or tertiary hypothyroidism is based on age and comorbid cardiac conditions, as described in Table 1. For patients at risk of atrial fibrillation or patients with underlying cardiac disease, start with a lower dosage and titrate the dosage more slowly to avoid exacerbation of cardiac symptoms. Dosage titration is based on serum TSH or free-T4 see Important Considerations For Dosing. Synthroid is prescribed in tablets that range from 25 to 300 mcg in strength and is usually taken once a day with a full glass of water (about 8 ounces) 30 to 60 minutes before breakfast for best adsorption into the body. Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension.

Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain. Get medical help right away, if you have any of the symptoms listed above. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Synthroid only for the indication prescribed.

Thuốc levothyroxine có những dạng và hàm lượng nào?

• The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
• Monitor patients receiving concomitant SYNTHROID and sympathomimetic agents for signs and symptoms of coronary insufficiency.
• Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract.
• Inquire whether patients are taking biotin or biotin-containing supplements.
• Because of the increased prevalence of cardiovascular disease among the elderly, initiate SYNTHROID at less than the full replacement dose see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS.

However, you may not be able to take this medicine if you have certain medical conditions. The major pathway of thyroid hormone metabolism is through sequential deiodination. Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination.

• Addition of levothyroxine therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements.
• It may take several weeks before your body starts to respond to Synthroid.
• Since postpartum TSH levels are similar to preconception values, the SYNTHROID dosage should return to the pre-pregnancy dose immediately after delivery see DOSAGE AND ADMINISTRATION.
• Ensure the patient ingests the full amount of the suspension.

Antidepressant Therapy

Levothyroxine is generally synthroid jsp continued for life in these patients see WARNINGS AND PRECAUTIONS. SYNTHROID increases the response to oral anticoagulant therapy. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased.

If cardiac symptoms develop or worsen, reduce the SYNTHROID dose or withhold for one week and restart at a lower dose. Seizures have been reported rarely with the institution of levothyroxine therapy. SYNTHROID tablets should be protected from light and moisture. The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks. Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see DRUG INTERACTIONS. Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter.

Tác dụng phụ thường gặp khi dùng thuốc levothyroxine

Monitor serum free-T4 levels and maintain in the upper half of the normal range in these patients. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. Levothroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma …

Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum. The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%. T4 absorption is increased by fasting, and decreased in malabsorption syndromes and by certain foods such as soybeans. In addition, many drugs and foods affect T4 absorption see DRUG INTERACTIONS.

Hypothyroidism

Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestationsof toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

Important Administration Instructions

Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. In adult patients with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dosage. In patients on a stable and appropriate replacement dosage, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient’s clinical status. Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation.

Armour Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid … Your child’s dose needs may change if the child gains or loses weight. SYNTHROID is contraindicated in patients with uncorrected adrenal insufficiency see WARNINGS AND PRECAUTIONS.